SNPwatch: Breathe Easier…New Insights From Asthma Research

Editor’s note: Pending an FDA decision, 23andMe no longer offers new customers access to health reports referred to in this post. Customers who purchased prior to November 22, 2013 will still be able to see their health reports, but those who purchased after that time will not. Those customers will have access to ancestry information as well as access to their uninterpreted raw data.

Coughing, wheezing, lungs encased in steel (or so they seem) … asthma makes breathing a challenge for nearly 25 million Americans of all ages. Despite the overwhelming number of people affected, this disease continues to be difficult to understand and to treat.

Asthma is divided into two main categories depending on the age of onset. Childhood-onset asthma develops early, before age 16, but may persist as a life-long condition. This subtype of disease is more common in boys than in girls and is often associated with allergies (in some populations). Adult-onset asthma typically develops in middle age and tends to be more prevalent in women than in men. Unlike its early-onset counterpart, later-onset asthma is not necessarily linked to allergy sensitivity and may be more resistant to treatment.

Asthma shows a strong family component, highlighting a role for genetics in a person’s risk for disease development. But, can we find the risky SNPs? In a recent publication from the New England Journal of Medicine, a group of researchers from a large consortium of asthma studies compared genotypes from more than 25,000 people of European ancestry (roughly 10,000 individuals with diagnosed asthma and more than 15,000 unaffected individuals) to determine potential genes involved in different asthma subtypes.

Although many SNPs identified in this investigation are linked to disease risk at any age, results indicate that one gene region on chromosome 17 (represented by ) is specifically associated with childhood-onset asthma only. Even among the SNPs linked with asthma risk in general, nearly all demonstrated a stronger effect in childhood rather than later-onset disease. Data did not reveal any genetic influence contributing uniquely to asthma severity or development risk from workplace exposure. The authors also investigated whether SNPs associated with asthma risk corresponded to SNPs known to regulate allergy sensitivity since the two conditions are often linked. Results suggest very little overlap between these two sets of SNPs, leading the authors to speculate that allergy sensitivity is an effect of asthma rather than its cause.

(23andMe customers can check their data for six of these SNPs using the Browse Raw Data feature. See table at the end of this post.)

Many of the SNPs identified in this paper are located in genes associated with the immune system’s communication network. Just like human armies, the cellular infantry of your immune system sends messages to coordinate its attack on harmful invaders. The genes implicated in this study act to communicate alarm signals from damaged airway tissue to immune cells, triggering the airway inflammatory response often associated with an asthmatic attack. This insight into the genetic culprits underlying the development of asthma may help reveal new targets for therapeutic intervention.

SNPs associated with asthma risk

SNP Nearest Gene Risk Version Odds Ratio
IL18R1 A 0.87
IL33 C 1.20
SMAD3 A 0.89
*
(childhood-onset only)
GSDMB A 0.76
IL2RB A 0.89
IL13 C 0.87

 

 

 

 

 

 

*All SNPs reported in this table are associated with both childhood-onset and later-onset asthma unless otherwise stated.

 

SNPwatch gives you the latest news about research linking various traits and conditions to individual genetic variations. These studies are exciting because they offer a glimpse into how genetics may affect our bodies and health; but in most cases, more work is needed before this research can provide information of value to individuals. For that reason it is important to remember that like all information we provide, the studies we describe in SNPwatch are for research and educational purposes only. SNPwatch is not intended to be a substitute for professional medical advice; you should always seek the advice of your physician or other appropriate healthcare professional with any questions you may have regarding diagnosis, cure, treatment or prevention of any disease or other medical condition.

 






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