|SNP||Version Associated with Delayed Tooth Eruption and/or Smaller Number of Teeth at Age 1|
*= association not significant for tooth eruption; **= association not significant for number of teeth at age one.height, another highly heritable and complex human trait, the variations the researchers linked with teething characteristics explain only a tiny fraction—about 3-4%—of the total variance seen in the population. More studies, with larger samples, will be needed in order to identify more SNPs, including those with smaller effect sizes and rare variants.Based on the significant SNPs listed above, the authors defined a summary statistic called the “delayed tooth eruption measure,” which is calculated by adding up how many copies of the “delayed” version of each SNP a person carries. For women the total possible is 10 (two copies of each of five SNPs). Because one of the SNPs is on the X chromosome, for men the total possible is nine.Based on the Finnish sample, the researchers calculated that individuals with a delayed tooth eruption measure of eight or more have an average of 1.5 fewer teeth at 12 months of age, and later tooth eruption by 1.1 months, compared to individuals with a score of three or less.The researchers also evaluated whether or not any of the SNPs found in their study of infant teething were associated with the need for orthodontic treatment by age 31 in their Finnish sample. The only significant finding was a SNP that showed only suggestive evidence for an association with timing of first tooth eruption and number of teeth at age one (i.e., it is not in the table above). Each G at rs6504340 increased the odds of requiring orthodontic treatment by 1.35 times.All of the SNPs identified in this study are in or around genes known to have roles in organ formation, growth and development, or cancer. The authors suggest that studies of teething and other aspects of infant development may have far reaching implications.“The discoveries of genetic and environmental determinants of human development will help us to understand the development of many disorders which appear later in life. We hope also that these discoveries will increase knowledge about why fetal growth seems to be such an important factor in the development of many chronic diseases, ” said Professor Marjo-Riitta Jarvelin, the study’s senior author, in a press release.SNPwatch gives you the latest news about research linking various traits and conditions to individual genetic variations. These studies are exciting because they offer a glimpse into how genetics may affect our bodies and health; but in most cases, more work is needed before this research can provide information of value to individuals. For that reason it is important to remember that like all information we provide, the studies we describe in SNPwatch are for research and educational purposes only. SNPwatch is not intended to be a substitute for professional medical advice; you should always seek the advice of your physician or other appropriate healthcare professional with any questions you may have regarding diagnosis, cure, treatment or prevention of any disease or other medical condition.