Comments on: Studies Identify Five More Genetic Variants Associated with Alzheimer’s http://blog.23andme.com/23andme-research/snpwatch/studies-identify-five-more-genetic-variants-associated-with-alzheimers/ Personal genetics for health, ancestry and research discoveries. Fri, 17 May 2013 21:38:47 +0000 hourly 1 http://wordpress.org/?v=3.4.2 By: Shwu http://blog.23andme.com/23andme-research/snpwatch/studies-identify-five-more-genetic-variants-associated-with-alzheimers/comment-page-1/#comment-30580 Shwu Fri, 08 Apr 2011 16:29:19 +0000 http://spittoon.23andme.com/?p=8809#comment-30580 Hi Steve, The table includes the letter or version of the SNP that is associated with the odds ratio that is also listed in the table. So, for example, the "A" version of rs6701713 is associated with a change in odds of developing Alzheimer's by a factor of 1.17. That means having one copy of an A there increases your odds by 1.17 times, and having two copies increases your odds by 1.17*1.17, or 1.37 times. Welcome to the service! Hi Steve,

The table includes the letter or version of the SNP that is associated with the odds ratio that is also listed in the table. So, for example, the “A” version of rs6701713 is associated with a change in odds of developing Alzheimer’s by a factor of 1.17. That means having one copy of an A there increases your odds by 1.17 times, and having two copies increases your odds by 1.17*1.17, or 1.37 times.

Welcome to the service!

]]> By: Steve Tsuida http://blog.23andme.com/23andme-research/snpwatch/studies-identify-five-more-genetic-variants-associated-with-alzheimers/comment-page-1/#comment-30497 Steve Tsuida Fri, 08 Apr 2011 07:30:57 +0000 http://spittoon.23andme.com/?p=8809#comment-30497 The table above uses a single letter for the version associated with each SNP, but in our 23andme.com raw data the genotypes list two letters, which of the two matters in this case, or is it a matter of even having one match? (I just started using 23andme.com—my results went online on April 4th—and I’m totally new to to all things genetics, so that was probably a dumb question.) The table above uses a single letter for the version associated with each SNP, but in our 23andme.com raw data the genotypes list two letters, which of the two matters in this case, or is it a matter of even having one match?

(I just started using 23andme.com—my results went online on April 4th—and I’m totally new to to all things genetics, so that was probably a dumb question.)

]]> By: Vladimir and Maureen Markov http://blog.23andme.com/23andme-research/snpwatch/studies-identify-five-more-genetic-variants-associated-with-alzheimers/comment-page-1/#comment-30444 Vladimir and Maureen Markov Fri, 08 Apr 2011 00:51:17 +0000 http://spittoon.23andme.com/?p=8809#comment-30444 Thank you for reporting on this here. M&V Thank you for reporting on this here. M&V

]]> By: Shwu http://blog.23andme.com/23andme-research/snpwatch/studies-identify-five-more-genetic-variants-associated-with-alzheimers/comment-page-1/#comment-30380 Shwu Thu, 07 Apr 2011 17:08:27 +0000 http://spittoon.23andme.com/?p=8809#comment-30380 The SNP required to determine APOE ε4 did not perform up to our standards of quality control on the previous version of the genotyping platform (v2). It seems to be working much better on the latest version (v3) but still needs to pass several more checks before we can report on it. Stay tuned! The SNP required to determine APOE ε4 did not perform up to our standards of quality control on the previous version of the genotyping platform (v2). It seems to be working much better on the latest version (v3) but still needs to pass several more checks before we can report on it. Stay tuned!

]]> By: Chris http://blog.23andme.com/23andme-research/snpwatch/studies-identify-five-more-genetic-variants-associated-with-alzheimers/comment-page-1/#comment-30376 Chris Thu, 07 Apr 2011 17:01:18 +0000 http://spittoon.23andme.com/?p=8809#comment-30376 So 23andme does not gather data for the APOE ε4relevant SNPs on their chips? So 23andme does not gather data for the APOE ε4relevant SNPs on their chips?

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