Category: 23andMe Research

SNPwatch: Genetic Variations May Impact Risk of Hearing Loss in Children Receiving Common Chemotherapy Drug

Cisplatin, a cancer chemotherapy drug first approved by the FDA in 1978, revolutionized the treatment of many types of cancer.  Despite its effectiveness, in many cases doctors are forced to reduce the drug's dose, or abandon it altogether, due to serious side effects on patients' hearing. Between 10-25% ...

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Research participants have a right to their own genetic data

The Kaiser Permanente Research Program on Genes, Environment and Health (RPGEH) is an exceptional study that has the potential to transform medicine.  As someone who proudly spent over 25 years as a patient with Kaiser, I would be excited to see my family's medical records used for such a worthy cause.  I was ...

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SNPwatch: The Bad Driving Gene?

New research suggests that your skills behind the wheel may be affected by your genes. To better understand the effects of a variant in the BDNF gene on motor skills learning, Steven Cramer and colleagues at UC Irvine tested 29 subjects in a driving simulator. Their results, published in the journal ...

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SNPwatch: New Variants Associated With Lupus in Europeans and Asians

Lupus, which means "wolf" in Latin, gets its name from the skin manifestations sometimes seen in the disease. A physician in the 13th century thought they looked like wolf bites. In autoimmune disorders, the immune system — which normally protects us from harmful, foreign substances — goes into overdrive ...

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SNPwatch: Two Large Studies Identify More Variants Associated with Blood-Related Traits

Previously in The Spittoon, we discussed two papers that identified genetic variants associated with hemoglobin levels in circulating blood. But blood consists of much more than hemoglobin, and it is responsible for much more than just transporting oxygen. This week Nature Genetics published the results of ...

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23and¡Mi Cabeza!: A New Migraine Headache Survey

Here’s how it goes for me: a few afternoons a year, usually when I haven’t slept or eaten right, but sometimes for no apparent reason, I begin to sense a pressure behind my left eyebrow and to feel queasy. By now I know what’s coming, and I resign myself to another miserable evening and a coming day or two ...

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SNPwatch: Genetic Variations Influencing Hemoglobin Levels Identified

Doctors routinely order the complete blood count (CBC) for their patients because they can learn a lot about a person's health by measuring the numbers of different types of blood cells in the circulation, their sizes and the ratios between them. One component of the CBC is usually a measure of the total ...

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SNPwatch: The Plot Thickens For Thinning Bones

Our bones are amazing structures, capable of supporting tremendous force through complex motions. They do this day in and day out, year after year as we sit, stand, walk, run, lift, work, and play. But as the elderly among us know all too well, bones are not invincible and become more fragile as we age. As ...

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SNPwatch: Genetic Clues to Bowel Disease Found in Mice and Men

Inflammatory bowel disease (IBD), which can appear as either ulcerative colitis or Crohn's disease, damages the lining of the digestive tract and leads to abdominal cramps, incomplete digestion and nutritional deficiencies. Previous research on IBD gave researchers reason to suspect that the CD39 gene, ...

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SNPwatch: Researchers Find More Genetic Variants Associated With Prostate Cancer

In the United States, prostate cancer affects about one in every six men.  Genomewide association studies aimed at finding common genetic variants associated with this common disease have been particularly successful. More than a dozen SNPs have been associated with prostate cancer, but researchers calculate ...

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