French Canadians aren’t the only group with higher rates of certain diseases, but they are unique in that they can trace their ancestry both genetically and through genealogical records generated by the Roman Catholic Church. Some researchers have even begun to pinpoint which founding immigrants first introduced the stowaway mutations into their new home of Quebec.23andMe Health Reports on Genetic Disorders Relevant to French Canadians
|Condition||About the Condition||Incidence*||Mutations Reported by 23andMe|
|Cystic Fibrosis||A serious lung condition characterized by excess mucus in the lungs.||1 in 900*||Three of the most important mutations for French-Canadian ancestry: DeltaF508, 621+1G>T, A455E.|
|ACCPN (also known as Andermann syndrome)||A neurodevelopmental disorder characterized by progressive inability to move, feel, and think clearly.||~ 1 in 2,000*||The T813fsX813 mutation, which accounts for over 99% of mutations in the French-Canadian population.|
|ARSACS||A neurodegenerative disorder characterized by muscle spasticity and lack of muscle coordination.||~ 1 in 2,000*||The 6594delT mutation found in over 90% of affected individuals with French-Canadian ancestry.|
|Leigh Syndrome, French Canadian Type (LSFC)||A metabolic and neurodevelopmental disorder that has only been described in individuals with French-Canadian ancestry.||~ 1 in 2,000*||The A354V mutation found in about 98% of identified cases.|
|Tyrosinemia Type I||A severe liver and kidney disorder.||~ 1 in 2,000*||The IVS12+5G>A mutation, which accounts for about 90% of mutations in the French-Canadian population.|
* Babies born per year with the condition. Numbers are specific for the Saguenay-Lac-St-Jean and/or Charlevoix regions of Quebec.