SNPwatch: Genetic Variant May Increase Risk of Follicular Lymphoma

SNPwatch gives you the latest news about research linking various traits and conditions to individual genetic variations. These studies are exciting because they offer a glimpse into how genetics may affect our bodies and health; but in most cases, more work is needed before this research can provide information of value to individuals. For that reason it is important to remember that like all information we provide, the studies we describe in SNPwatch are for research and educational purposes only. SNPwatch is not intended to be a substitute for professional medical advice; you should always seek the advice of your physician or other appropriate healthcare professional with any questions you may have regarding diagnosis, cure, treatment or prevention of any disease or other medical condition.

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Researchers have identified a genetic variant that increases risk of follicular lymphoma (FL), a type of blood cancer.

FL is a type of Non-Hodgkin lymphoma (NHL), the fifth most common cancer in the U.S. Nearly 20,000 patients die and 66,000 more are diagnosed with NHL each year. The incidence of FL has doubled within the past 30 years.

In a study by Skibola et al., scientists analyzed the genomes of 4,805 people of European descent from the United States, Germany and Canada to search for genetic associations with four different subtypes of lymphoma. The results, published online this week in the journal Nature Genetics, newly linked one SNP to an elevated risk for developing FL in European populations.

FL is a slow-progressing cancer of the white blood cells that affects middle-aged and elderly people. It is usually diagnosed in advanced stages, but patients live approximately 10 to 12 years after diagnosis.

Skibola et al. revealed that having one copy of the C version of rs6457327, a SNP located on chromosome 6, is associated with 1.69 times increased odds of FL compared to people with two copies of an A at this SNP. Carrying two copies of C at this SNP is associated with 2.22 times increased odds of FL. Because a majority of the population carries the C version, another way to look at these results is to say that those who have the A version of this SNP appear to be somewhat protected from FL.*

(23andMe customers can check their data for rs6457327 using the Browse Raw Data feature.)

This SNP is located near a region that is associated with susceptibility to psoriasis. The researchers said that further studies are required to evaluate whether rs6457327 is also associated with psoriasis due to this genetic overlap. Future research may also determine whether FL is associated with exposure to viruses such as HIV.






  • http://www.sciencedaily.com/releases/2009/07/090720134232.htm Lynn Foreman

    “Researchers found that, for SNP rs6457327, the presence of the G allele – a DNA letter that varies within the genome – was protective against follicular lymphoma, while the presence of the A allele was predictive of an increased risk of developing follicular lymphoma. Dr. Brown said individuals who had the A variant were nearly twice as likely to develop follicular lymphoma.
    “There’s clearly a genetic component to the disease. The hope is to one day be able to take these results, combine them with other tests, and turn them into an individualized assessment of disease risk,” said Dr. Brown, the study’s other co-lead author. “This is a starting point.”
    Dr. Skibola said more studies would be needed to determine the biological importance of other STG SNPs linked to rs6457327 that might change the function of the gene. This could help determine how they might influence risk of the disease.”

    Could you please if it is the a allele increases the risks ?

  • http://www.23andme.com ErinC

    Hi Lynn,

    Your quote comes from a story that appeared in Science Daily. I can see why you’re confused!

    The author of that story seems to have mixed up some of the facts about the SNP described in this blog post. The two possible versions are C and A, not G and A. And it is in fact the case that the more common C version is associated with increased risk. As the edited paragraph in the Spittoon post now explains more clearly (see the paragraph marked with a *), this really means that the less common A version is associated with protection against FL. It all depends which way you look at it. But one for thing is for sure, “A” is not the allele that increases risk.

    Science Daily article:
    http://www.sciencedaily.com/releases/2009/07/090720134232.htm

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