Comments on: SNPwatch: Genetic Variation May Increase Risk of Atrial Fibrillation And Stroke http://blog.23andme.com/news/snpwatch-genetic-variation-may-increase-risk-of-atrial-fibrillation-and-stroke/ Personal genetics for health, ancestry and research discoveries. Tue, 18 Jun 2013 18:06:31 +0000 hourly 1 http://wordpress.org/?v=3.5.1 By: MattC http://blog.23andme.com/news/snpwatch-genetic-variation-may-increase-risk-of-atrial-fibrillation-and-stroke/comment-page-1/#comment-2058 MattC Wed, 22 Jul 2009 17:48:10 +0000 http://spittoon.23andme.com/?p=4107#comment-2058 A common question, and a good one. Remember that you have two copies of every non-sex chromosome (and thus every SNP on those chromosomes), one from your father and one from your mother. If your genotype is CT, that means you got one version of that SNP from one parent, and the other version from the other parent.

As far as your risk goes, this study found that EACH copy of T increases your odds of developing AF by 1.21 times, all other risk factors aside (e.g., blood pressure, age, alcohol consumption, other relevant genetic variations, etc.).

So the odds for a person with the TT genotype would be 1.21 times 1.21, or 1.46 times average.

Not all genetic associations like the one reported in this post follow that rule, however. In some cases, the effect is the same whether a person has one copy of the high-risk allele or two.

]]> By: togilvie http://blog.23andme.com/news/snpwatch-genetic-variation-may-increase-risk-of-atrial-fibrillation-and-stroke/comment-page-1/#comment-2057 togilvie Wed, 22 Jul 2009 13:46:54 +0000 http://spittoon.23andme.com/?p=4107#comment-2057 The post references “the T version”, and when I browse the raw data it says there’s a C and T version. If my genotype is CT, do I have the C version or the T version?

Is there some overview on this terminology?

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