Tag: GWAS

The Complex Genetic Architecture Underlying Human Differences

You’d be forgiven for assuming your height has nothing to do with the curl of your hair or how flexible you are, but physical traits can sometimes have unexpected connections. Last week at the annual meeting of the American Society of Human Genetics in San Francisco, 23andMe’s Principal Scientist and ...

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Breast Size Matters — But Not In The Way You Think

With Nick Eriksson Social norms and preferences aside, it turns out that breast size matters -- but not quite in the way you think. 23andMe’s latest research paper, published in the journal BMC Medical Genetics, shows that genetic factors influence whether women have double As or double Ds. This might ...

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23andMe’s Latest Publication Shines Light on Male Pattern Baldness and Unexpected Associations with Disease

A new paper in PLoS Genetics describes discoveries related to the genetics of male pattern baldness, with substantial contributions from the 23andMe community. Led by Dr. Brent Richards of McGill University, the study combined genome-wide association data from seven cohorts, comparing men with "early onset" ...

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SNPWatch: Genetic Variants Associated with Type 2 Diabetes in South Asians and Europeans

Type 2 diabetes is characterized by very high levels of sugar in the blood and is the most common form of diabetes. Although eating rich food and leading a sedentary lifestyle contribute to the development of this disease, genetics also play a role. For reasons unclear to researchers, people of South Asian ...

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Let’s Talk About Sex… in GWAS

By Bethann Hromatka The saying “men are from Mars, women are from Venus,” may have originated from personality differences between the sexes, but it also rings true for complex diseases that affect one sex more than the other. For instance, the prevalence of autoimmune diseases such as rheumatoid ...

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23andMe’s Third Publication Demonstrates Efficient Replication of Over 180 Genetic Associations

As we’ve mentioned here previously, science can be a slow process. Researchers spend a long time -- sometimes upward of five years -- gathering enough people with a particular disease to study, collecting samples and data from them, analyzing that data, and then publishing the results. Imagine if you had to ...

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23andWe Research Update: Something Old and Something New

One of 23andMe’s core missions is to accelerate the pace of scientific research and contribute to our understanding of the genetic basis of human health and traits. Central to this mission is our growing database of genotyped customers who have consented to allow us to incorporate their genetic data and ...

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Better Understanding of Colorectal Cancer-Associated SNP Could Guide Treatment

Much to the surprise of many scientists, a lot of the SNPs identified in genomewide association studies have not been in the parts of genes that encode the molecular machinery of a cell. Instead, many SNPs have been found on the edges of genes, in regions of DNA that control when the genes get turned on or ...

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Researchers Look For Common Themes In Bipolar Disorder Genetics

Genomewide association studies have had some success in finding DNA variants associated with increased risk for bipolar disorder.  But researchers from the MRC Centre for Neuropsychiatric Genetics and Genomics at Cardiff University in England have taken these studies a step further by looking for common ...

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It’s Your Data … Shouldn’t You Have Access To It?

Each one of us carries in our cells the vital genetic data, compliments of our parents, that code for many of our traits and attributes.  Whether it's our eye color, height or the ability to consume dairy products, the variations in our genes contribute to making us 'one of a kind'.  Unfortunately, these ...

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