In this example of an ancestry painting from 23andMe, an African-American woman has DNA that traces to Europe (blue), Africa (green) and Asia (orange). Theoretically, a genetic factor identified in Europeans could be applicable if she inherited the version of the genetic factor tracing to Europe as opposed to the version tracing to Africa or Asia. It isn’t always this straightforward, however, and association studies should be carried out in African American cohorts in order to confirm or negate that the genetic factor is applicable.Bridging the gap in research is particularly important for diseases that affect African Americans more than the rest of the population. Prostate cancer is a prime example. African American men have the highest rate of prostate cancer in the United States and are more than twice as likely as men of other ethnicities to die of the disease (62% in African American males versus 26% in American males of European descent). These numbers are staggering and point to disparities not only in medical access and treatment, but also in scientific research. At 23andMe we strive to provide meaningful genetic health reports to individuals of all ethnicities but are often hampered by the lack of published studies in non-Europeans. Our Established Research report on prostate cancer reflects this lack of research and currently includes three markers for African Americans while reporting 12 markers for people with European ancestry. The need for more research involving African Americans is further supported by recent studies showing that many factors linked to prostate cancer in European populations aren’t applicable to African Americans and by the fact that less than one-third of our current health reports provide results applicable to people with African ancestry. 23andMe recognizes that research has lagged in this area and in an effort to reverse this trend has launched Roots into the Future, an initiative aimed at discovering connections between DNA and disease in 10,000 African Americans. Enrollment for this study is near completion, but individuals who identify as African American, Black, or African can still contribute to research by signing up as customers of 23andMe and answering surveys about their health. Our aim is to provide disease risk reports for everyone – regardless of their ancestral origins – and you can be a part of this exciting process. February is Black History Month – see our previous posts on sickle cell disease and African ancestry!
trace their ancestry to both Africa and Europe and it isn’t straightforward to figure out which pieces of their chromosomes came from each continent, something that is important for teasing out links between DNA and disease.