Editor’s note 2/6/2013: Pending an FDA decision, 23andMe no longer offers new customers access to health reports referred to in this post. Customers who received their health information prior to November 22, 2013 will still be able to see their health reports, but those who purchased after that time will only have access to ancestry information as well as access to their uninterpreted raw data. These new customers may receive health reports in the future dependent on FDA marketing authorization.
For back-to-school month we’re running a series of posts on genetic factors that may impact learning. Here we describe a variant that may influence a person’s ability to learn from their mistakes. In a prior post we discuss a variant linked to non-verbal IQ performance.
Why do some people have a hard time learning from their mistakes?
It might have to do with genetics. At least one research study suggests that the tendency to make rewarded choices while avoiding those that receive negative feedback may be influenced by genetics.
In this study, 26 German individuals took a test that assessed their ability to prefer “correct” choices and avoid “incorrect” ones. The authors genotyped the subjects at the SNP rs1800497, which is thought to affect a gene involved in dopamine signaling. The neurotransmitter dopamine is involved in trial-and-error learning and variations in genes related to dopamine signaling may also affect a person’s ability to learn.
People with the GG genotype at rs1800497 learned to avoid choices associated with negative feedback relatively easily, while people with the AG or AA genotypes did not learn as well to avoid these “punished” choices; in other words, they did not learn from their mistakes. The AG and AA genotypes have also been correlated with up to a 30% reduction in dopamine receptor density in a region of the brain known as the striatum.
(Rs1800497 is commonly referred to in the scientific literature as the DRD2 TaqIA polymorphism. The A version of rs1800497 is equivalent to the A1 allele of DRD2 TaqIA, while the G version of the SNP corresponds to the A2 allele.)
If you’re looking for a genetic excuse, this is a good one to point to. The next time your spouse is amazed that you left the house again without your phone … or house keys … just say that you’re genetically predisposed to not learn from your mistakes.
The results presented here were obtained with a very small sample size and have not been independently replicated. While the results are intriguing, it’s important to realize that learning is an extremely complex behavior that is also strongly influenced by environment.