Pregnancy and MTHFR

Editor’s note: Pending an FDA decision, 23andMe no longer offers new customers access to health reports referred to in this post. Customers who received their health information prior to November 22, 2013 will still be able to see their health reports, but those who purchased after that time will only have access to ancestry information as well as access to their uninterpreted raw data. These new customers may receive health reports in the future dependent on FDA marketing authorization.

Ed Note: Apparently not all genes are created equally. There are a few, like MTHFR, that draw a lot of attention. While there is much interest regarding variants within the MTHFR gene and their associations with different conditions, much of the research done so far on those variants is inconclusive. Below is a post that looks at MTHFR’s role in reproduction.DNA Strand

The MTHFR gene codes for a protein that helps people metabolize B-vitamin folate (also called folic acid or vitamin B9). Relatively common variations in the DNA sequence — the order of A’s, T’s, G’s and C’s in the gene — can impact how someone metabolizes folate and, in some instances, can impact your health.

People with slight impairments in folate metabolism are usually perfectly healthy since they consume enough folate in their diets to make up for their reduced ability to break it down. But there are situations — namely during pregnancy — when women with a particular variation in the MTHFR gene called C677T should consume more folate to prevent birth defects. Although all pregnant women are advised to take folic acid supplements because this nutrient is vital for early fetal development, women with the C677T genetic variant appear to need even more of it.

Scientists have also investigated if the MTHFR gene impacts a woman’s ability to carry a pregnancy to term, but findings aren’t completely convincing. Some studies have found an association between miscarriage and MTHFR variants including C677T in certain populations, but other studies have failed to see a connection. One study added a twist by suggesting that some MTHFR variants predispose for chromosomal abnormalities in the embryo that are incompatible with life and lead to miscarriage. But this study was relatively small and has not been replicated.

Some prospective mothers with a history of miscarriages are being told to test for MTHFR variants with the advice that it ‘can’t hurt.’ But the evidence is that it might not actually do any good either.

Regardless of whether the MTHFR variants influence miscarriage, low folate levels and hyperhomocysteinemia in the mother have been linked to recurrent miscarriage. Some women may undergo testing for folate levels or hyperhomocysteinemia if they’ve had multiple miscarriages.

Understanding why miscarriage occurs in the first place is still an active area of research. At least half of miscarriages arise due to major genetic abnormalities in the embryo (for instance missing an entire chromosome). But other factors such as hormonal changes, diet, or whether a woman drinks alcohol or smokes, may also play a role.

Researchers have also studied the MTHFR gene in the context of male infertility. But similar to the case of miscarriage, there isn’t convincing evidence that genetic differences in this gene influence fertility in men.

The Role of MTHFR in Healthhealth_caduceus

The MTHFR gene codes for a protein called methylenetetrahydrofolate reductase that converts one form of folate (5,10-methylenetetrahydrofolate) into a different form of folate (5-methyltetrahydrofolate).

This step in folate metabolism is required for another chemical reaction in the body — specifically for the conversion of an amino acid called homocysteine into another amino acid called methionine that is important for building proteins.

Mutations that cause the MTHFR protein to malfunction may in turn cause someone to accumulate too much homocysteine and develop a condition called hyperhomocysteinemia. Hyperhomocysteinemia has been tentatively linked to a variety of conditions including cardiovascular disease, stroke, and Alzheimer’s disease.






  • Elissa Leonard

    MTHFR is not only about folate it is about B12. B vitamins work in synergy. Folic acid (synthetic form of folate) should never be given to people unless B12 status is normal. High folic acid in prenatal vitamins and the food supply will “mask” a B12 deficiency, which is a vulnerability women and their children with MTHFR variants have.

    If “more folic acid” were the answer, we would not have explosion of pregnancy related problems in women in the wake of more and more folic acid being added to prenatal vitamins and flour products.

    People with MTHFR variants need ample B12 and folate (real folate, from food, is best) Opposite extremes of B vitamin status — high synthetic folic acid in the presence of low B12 — increases disease risk in all age groups. Folic acid builds up in some people, unmetabolized. You cannot metabolize folic acid if you are low in B12 or you have certain gene variants.

    The masking issue is not theoretical, it causes needless suffering in all age groups.

    Sincerely,

    Elissa Leonard, Producer
    Diagnosing and Treating B12 Deficiency
    In the Age of Folic Acid Fortification
    http://youtu.be/BvEizypoyO0

    ps I recently received this note from a pediatrician who saw my documentary:

    b-12 video
    Thanks for your important video. I’m a pediatrician and have found countless autism and spectrum / ADHD / anxiety etc patients to be B-12 deficient and respond nicely to methyl-B 12 shots (with folate) or oral / sublingual B12.

    Could it Be B-12 deficiency was a great book

    below is my latest you tube video on this topic (just an intro) not as thorough as yours.

    thanks
    Dr Paul
    drpaul.md
    Thumbnail 5:08
    Why You Should Be Taking Vitamin B-12 | Pediatric Advice
    http://www.youtube.com/watch?v=8JVJKBwDCd8

  • woody voinche

    What research have you done on adult stem cells to replace the degenerated
    dopamine producing cells in the substantia nigra…there have been a lot of successful treatments using this method….goodle… adult stem cells and parkinsons….

    i have parkinsons and am researching this ….

  • http://www.sistersraisingsisters.com Mustang Sally

    Thank you for the article. I wanted to share my story with you and your readers in case there were women out there stuggling with MTHFR and pregnancy. After a miscarriage, I was diagnosed Compound Heterozygous for MTHFR and after a tough pregnancy was able to deliver a healthy baby. Take heart, it can be done!

    Read the whole story here: http://www.sistersraisingsisters.com/every-birth-is-beautiful-mthfr-and-a-healthy-baby-my-pregnancy-story/

  • Afiq Zamri

    After reading this article I understand the idea of chromosomal abnormalities in embryo and it’s association with miscarriage. But in some cases, they are babies that were born with abnormalities in chromosomal number and their mother did not miscarriage during pregnancy. So, the chromosomal abnormalities in embryo cannot be really proven to be true in leading pregnancy to miscarriage due to this situation. Also, this is only my point of view. More researches should be done regarding the association of chromosomal abnormalities and the miscarriage in order to prove this theory.

  • Jeremiah

    could the MTHFR variants be the reason of miscarriage that it produces a protein that causes miscarriage? or somehow affects the proper formation of chromosome?

  • Jeremiah

    will the accummulation of homocysteine causes the miscarriages?

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