Did Neanderthals and Humans Mate? Absence of Evidence is Not Evidence of Absence

The Spittoon has pointed out several times in the last few months (here, here and here) that when researchers look for evidence of interbreeding between early humans and Neanderthals, they often fail to find any.

But there are still a number of geneticists who would like us to pay heed to the words of former defense secretary Donald Rumsfeld, who once pointed out that “the absence of evidence is not evidence of absence.”

During a briefing for science writers this morning at Stanford University, geneticist Bruce Lahn argued that interbreeding with Neanderthals may have introduced into the human gene pool a mutation that appears to confer an evolutionary advantage with regard to brain development.

“We argue that in modern humans there may actually be some Neanderthal genes,” Lahn said at the Council for the Advancement of Science Writing’s New Horizons in Science briefings.

Lahn based his argument on a gene known as microcephalin. Because certain mutations in the gene can cause underdevelopment of the brain, microcephalin is assumed to be involved in that organ’s development.

Lahn described research that he and several colleagues first described two years ago in the Proceedings of the National Academy of Sciences. The researchers sequenced microcephalin in 89 people from populations around the world. They found that the sequences fell into two very different groups — so different, in fact, that they apparently traced back to a common ancestor older than the human species itself.

Moreover, each of the two groups appeared to have a very distinct history of its own. One appeared to have arisen about a million years ago, and diversified at a steady pace since then. The other group, however, appeared to have arisen just 37,000 years ago and spread rapidly throughout 70% of the human population. That kind of pattern suggests what evolutionary biologists call a “selective sweep,” the introduction of an advantageous genetic variant that quickly wipes out older versions of the gene.

Usually when geneticists see a selective sweep in action, the new variant appears to arise out of the pre-existing one. But in this case, Lahn argues, the new genetic variation traces back to a common ancestor that precedes both populations. He believes Neanderthals could have been that population, and that they could have transferred the “new” variation to the into the human gene pool through interbreeding about 40,000 years ago.

It’s just a hypothesis at this point — and one that many geneticists consider difficult to confirm. But if ongoing efforts to sequence the Neanderthal genome find a version of the microcephalin gene identical to the one that is currently sweeping through the human population, Lahn will have strong evidence for his claim.

Photo: K. Mowbray

  • http://cognections.typepad.com/lifeblog cschick

    Interesting. I keep thinking about this, too (and not because I read Clan of the Cave Bear series).

    Modern humans and Neandertals overlapped for thousands of years. To interbreed, they would have to overcome not only the size of Europe, but population densities and cultural differences (and likely taboos). Yet, thousands of years is a long time and for sure there was interbreeding. The question then is if that interbreeding contributed or can be seen in our own modern genomes.

    The other question I have is what cultural things we picked up from Neandertals and vice versa. How might we trace that?

  • Chloeanne.

    This is really interesting, im doing some course work and im in year ten, this subject is really confusing to me, BUT this has helped and has made me think more about the subject.
    I know that Giorgio Bertorelle tryed to compare the DNA from both Neanderthals and Humans and also Cro-Magnons and it turned out that there was a close match between not Neanderthals and Humans but Cro-Magnons and Humans. But many people dont agree with his conslusion as teh differences tested were too small to draw any conclusion.
    This is all soooo confusing.
    And i’ve got this courework due in tomorow.
    Im dead.

  • DL

    Actually, Dr. Carl Sagan was the one who coined “the absence of evidence is not evidence of absence.”

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