“I now have the opportunity to adjust my life to reduce those odds (e.g. there is evidence that exercise may be protective against Parkinson’s). I also have the opportunity to perform and support research into this disease long before it may affect me. And, regardless of my own health it can help my family members as well as others.”
There are a number of LRRK2 mutations that substantially increase Parkinson’s risk. The one Brin has, which is known as G2019S, is most commonly found among people of Ashkenazi Jewish and North African descent. It has occasionally been found in some non-Jewish European populations, but is virtually unknown in East Asia.Any customers who want to know their LRRK2 G2019S status now can find out by using the 23andMe Genome Browser to search for their genotype at the SNP rs34637584. Having one or two copies of the A version of this SNP substantially increases a person’s chances of developing Parkinson’s Disease.Our upcoming Parkinson’s Disease entry will offer much more complete information about the significance of having or not having the G2019S mutation. In the coming weeks and months we plan to provide much more information about Parkinson’s and many other diseases, conditions and traits that are affected by genetics. We hope that like Sergey, you’ll want to join us on this exploration of the genetic frontier.