Genetic Armor in Flu Season

A sure way to make you more diligent about washing your hands is to read a little coverage on what’s turning out to be the worst flu season in recent memory.A lucky few of us, however, have defenses that go beyond trusty soap and water – our genes. Approximately 30 percent of people with European ancestry and 20 percent of those with African ancestry carry a mutation that gives them extra protection against the most common strains of norovirus. Norovirus is one of the three flu or flu-like viruses now spreading across the globe during this sick season.What is making this so bad is what the New York Times describes as “the convergence of three flu or flu-like epidemics” hitting all at once. These three illnesses include   an unusually virulent flu virus,   a pretty nasty norovirus, and a whooping cough outbreak that’s as bad as it’s been in 60 years. As the article indicates, this is all happening “amid the normal winter highs for the many viruses that cause symptoms on the colds and flu spectrum.” Not a pretty picture for those who fret about getting ill.The Centers for Disease Control (CDC) is a little less breathless in its description of the flu season, but officials there are still heralding a warning nonetheless.“Reports of influenza-like-illness (ILI) are nearing what have been peak levels during moderately severe seasons,” according to the CDC’s Dr. Joe Bresee. The CDC continues to recommend flu shots as well as antiviral medication when appropriate.
So let’s zero in on the norovirus, which is sometimes described as the “stomach flu.” In reality, it isn’t the flu, but “viral gastroenteritis.” This nasty bug is hugely contagious and pretty unpleasant with symptoms that include abdominal pain, vomiting and diarrhea. It spreads quickly, especially in close quarters and can rapidly rip through schools, retirement communities and hospitals. This latest outbreak is hitting the US right as the flu is spreading. And this particular strain hit England a few weeks ago, making more than a million people ill, according to the Guardian.Some people, however, may be safer than most during this time of illness. About 30 percent of people with European ancestry and about 20 percent of those with African ancestry carry the AA version of SNP rs601338 in the FUT2 gene. For these lucky folks need not fear the most common strain of norovirus like the rest of us. They lack the molecules noroviruses use to enter the digestive tract cells.  It doesn’t mean they are bulletproof from getting sick, but they are protected against most strains of norovirus. Unfortunately, very few people of Asian ancestry carry the resistant genetic variant.Whether you belong to the fortunate ones who carry this extra genetic protection or not, it is still a good idea to keep washing those hands. If you haven’t already you also might consider getting a flu shot if available.
  • aaron

    why not post a link or at least tell those subscribers how to look up this gene in their profiles to see if they carry it.?

    • aaron

      never mind, I see it.

      • ScottH

        Hi Aaron,
        Glad you found it. In the future if you ever want to look up a specific SNP you can do so by selecting the “Browse Raw Data” option under the setting menu.

  • Stephanie

    This is useful and well written as well as being timely. The little box with my family’s results is perfect. More, please!!

  • StephenB

    I’m GG, not AA. Both my kids (8 & 12) got it in quick succession, but either I didn’t get it or didn’t notice it. I must be doing something else right. 😉

  • Phil Jackson

    I really the the widget. More like this. It’s great to be a customer and see the exact relevant info inside the article related to my own genetic makeup

  • Can you find out whether or not you have this AA gene with the genetic test that you do?

    • 23blog

      Hi Sara,
      You can look up that particular variant – rs601338 – in your raw data.

  • Jason Wortham

    Um, I have the genetic immunity gene. My daughter picked up the illness from her pre-school (school said Norovirus was recently present, one kid and one teacher had it). Standard symptoms, so it seemed likely it was indeed Norovirus. Two days later my wife AND I got it. Wife is AG, so not immune. But I am AA. Why the heck did I get sick?

    Well, it turns out the immunity is not 100%. There are some strains of Norovirus which can bypass the immunity. See this case study of an entire family with the immunity genetics which nevertheless all got sick (confirmed Norovirus). Some of the less common strains bypass the immunity.

  • Josh Ward

    I looked up the rs601338 in my raw data and under “Your Genotype” it says A/A. Does that mean I’m less susceptible to the normal strains of norovirus?

  • etcbyte

    Well I am G;G (supposedly susceptible to most strains of Norovirus) and I haven’t had a vomiting/stomach illness in about 8 years. Not sure if that’s just normal anyway.

  • Beth Katehis

    The 23andme Snp rs601338 says I am Genotype A/A Non-Secretor, Norovirus Resistance and Vitamin B12 Quantitative.

  • Millie Iafelice Schaller

    last week we had 15 people here for a party. 2 days later 7 of them came down with norovirus symptoms. the interesting thing is the people who did not get sick were me, my husband, our 4 children and 2 grandchildren. Of the 7 who got sick 4 of them were married to my children and 3 were grandchildren. None of the initially nonstick caught it from their sick husbands or children despite close contact. I am from eastern European dissent so it seems our family has a pretty strong immunity.