PLoS Medicine, Shengxu Li and colleagues tackled a piece of that puzzle. Using a sample of 20,000 Europeans, they compared the predictive power of 12 SNPs known to influence BMI in sedentary and physically active individuals. While carrying a greater number of risky versions of these SNPs was associated with higher BMI in both groups, the association was much weaker in the physically active. In the sedentary group, each additional risky variant translated to a 0.21 increase in BMI, or an extra 1.3 lbs (592 g) for someone 5’7 (170 cm). By comparison, in the physically active people, each additional risky variant translated to a 0.13 increase in BMI, or an extra 0.8 lbs (397 g) for someone 5’7 (170 cm). Leading a physically active lifestyle, they concluded, was associated with a 40% reduction in the genetic predisposition to obesity. Although we only have 9 of the 12 SNPs covered in our database, a quick analysis using our customers’ data replicated their findings. Carrying more risky variants was predictive of a higher BMI overall, but this effect was much more pronounced among our customers who reported low levels of physical activity. Of course, the 12 SNPs under investigation do not represent the totality of genetic predisposition to obesity. In fact, the 12 SNPs combined accounted for only 1.2% of the variation in weight among the sedentary individuals, and even less, 0.6%, among the physically active. Other genetic factors not measured in this research, such as rare variants associated with BMI, likely play a role as well. SNPwatch gives you the latest news about research linking various traits and conditions to individual genetic variations. These studies are exciting because they offer a glimpse into how genetics may affect our bodies and health; but in most cases, more work is needed before this research can provide information of value to individuals. For that reason it is important to remember that like all information we provide, the studies we describe in SNPwatch are for research and educational purposes only. SNPwatch is not intended to be a substitute for professional medical advice; you should always seek the advice of your physician or other appropriate healthcare professional with any questions you may have regarding diagnosis, cure, treatment or prevention of any disease or other medical condition.