SNPwatch: Five New Studies Identify Genetic Variations Associated with Coronary Artery Disease and Heart Attack

SNPwatch gives you the latest news about research linking various traits and conditions to individual genetic variations. These studies are exciting because they offer a glimpse into how genetics may affect our bodies and health; but in most cases, more work is needed before this research can provide information of value to individuals. For that reason it is important to remember that like all information we provide, the studies we describe in SNPwatch are for research and educational purposes only. SNPwatch is not intended to be a substitute for professional medical advice; you should always seek the advice of your physician or other appropriate healthcare professional with any questions you may have regarding diagnosis, cure, treatment or prevention of any disease or other medical condition.

Lifestyle factors such as smoking or a high-fat diet are well-established contributors to heart attack risk, because they encourage the accumulation of sticky plaques inside the arteries that supply the heart with oxygen- and nutrient-rich blood.Though genetics plays an almost equal role in the accumulation of plaques in the coronary arteries, the specific genes involved in the process are largely unknown.   Only one region of DNA on chromosome 9 has consistently been linked to heart disease.(23andMe customers can learn more in the Heart Attack Research Report.)Now five studies, published online yesterday in the journal Nature Genetics, have identified a bumper crop of genetic variations associated with coronary artery disease (the build up of plaque) and heart attack.   Although more work will be needed to confirm these associations and figure out exactly how they affect risk, these results are a major step forward in understanding the biology of heart disease. Eventually the variations identified in these and future studies may be useful for prediction, prevention or treatment of coronary artery disease and heart attack.Four of the studies looked at the effects of individual SNPs on coronary artery disease or heart attack. 23andMe customers can check their data for many of these using the information at the end of this post. The fifth study looked at the effect of a combination of four SNPs.   23andMe cannot currently provide customers with the type of data described in this study.
Note: In each table, “Effect” refers to the increase in odds for each copy of the risk version compared to two copies of the non-risk version of the SNP.
Study: Myocardial Infarction Genetics Consortium Early-onset heart attack (men 50 years old or younger, women 60 years old or younger) Cases: More than 12,000 Controls: More than 12,000 Populations studied: European ancestry; United States, Sweden, Finland, Spain, Italy, U.K., Germany, Ireland and Iceland
SNPRisk VersionEffectNotes
rs646776T1.19
rs17465637C1.14Data available only to those customers who received their data after 9/1/08.
rs1746048C1.17
rs6725887C1.17
rs11206510T1.15

Study: Gudbjartsson et al. Heart Attack Cases: 6,650 Controls: 40,621 Populations studied: European ancestry; Iceland, United States, New Zealand and Italy
SNPRisk VersionEffectNotes
rs3184504T1.13Data available only to those customers who received their data after 9/1/08.

Study: Erdmann et al. Coronary Artery Disease Cases: 19,407 Controls: 21,366 Populations studied: European ancestry; United States, Sweden, Finland, Spain, Italy, U.K. and Germany
SNPRisk VersionEffectNotes
rs2306374C1.15This SNP is a proxy for rs9818870, the SNP found in the study.

Study: Ozaki et al. Heart Attack Cases: 3,337 Controls: 3,891 Population studied: Asian ancestry; Japan
SNPRisk VersionEffect
rs3782886C1.44