Nature Genetics, implicates three new areas of the genome in brain aneurysms. “When combined with traditional risk factors such as gender, blood pressure and smoking, these findings form the basis of future work aimed at preclinical identification of individuals who are at high risk of intracranial aneurysm formation and rupture,” the authors write. Many of the variations associated with increased risk for brain aneurysm are in or near genes involved in cell replication and differentiation. The researchers suggest that perhaps part of what causes an aneurysm is disruption of the normal cell proliferation process, or a change in the balance between stem cells and more specialized cell types. It’s known that siblings of people with brain aneurysms are at fourfold increase for the condition. Based on this fact and the effect sizes of the SNPs identified or confirmed in this study, the researchers think that their findings explain between three and five percent of the familial risk of brain aneurysm. This means that there is still a lot to learn about both genetic and non-genetic risk factors for the condition. SNPwatch gives you the latest news about research linking various traits and conditions to individual genetic variations. These studies are exciting because they offer a glimpse into how genetics may affect our bodies and health; but in most cases, more work is needed before this research can provide information of value to individuals. For that reason it is important to remember that like all information we provide, the studies we describe in SNPwatch are for research and educational purposes only. SNPwatch is not intended to be a substitute for professional medical advice; you should always seek the advice of your physician or other appropriate healthcare professional with any questions you may have regarding diagnosis, cure, treatment or prevention of any disease or other medical condition.