A new survey of 23andMe’s Health + Ancestry customers conducted by M/A/R/C® Research found that more than three-quarters reported that after receiving their personalized genetic reports they made at least one positive change in their health behavior.

Changes included eating healthier, getting more sleep, and exercising more, among others.

“We’re encouraged by these preliminary findings, and they’ve spurred us to embark on more comprehensive research into behavior change as a result of our service,” said Joyce Tung, 23andMe’s Vice President for Research. “We have heard from many customers who have offered stories about how their 23andMe results have positively impacted their lives, but we want more quantitative data.”

Taking Steps to Improve Health $\"\"$

Sleep, diet and exercise are key to good health, so understanding what might motivate people to make meaningful and positive changes is important. Two years ago, 23andMe researchers presented data at the annual meeting of the American Society of Human Genetics, showing that after viewing their 23andMe Saturated Fat and Weight report, customers reported making healthier dietary choices.

In this new survey, external researchers asked Health + Ancestry customers about the overall impact of their 23andMe experience, regardless of their results. Among those who responded to the survey 76 percent said they made one or more healthy changes to their lifestyles. Of those who responded to the survey:

55 percent reported healthier eating habits including eating more vegetables, and cutting out sugar and fast food.
45 percent said they were exercising more.
42 percent said they were getting more sleep.

The Survey

The survey, designed by 23andMe and M/A/R/C Research, and conducted online by M/A/R/C over two weeks in August 2019, included responses from 1,046 23andMe Health + Ancestry customers who have joined within the past two years.

While the responses are not representative of the US general population as a whole, they do offer preliminary insights worth studying further to gauge the impact of 23andMe results as a motivator for healthy behavior change.

Impact of Genetic Testing

There have been several other studies that have looked at the impact of genetic testing. Among the most notable has been the on-going work of the Impact of Personal Genomics Study (PGen), a collaborative effort led by scientists from the Broad Institute of MIT, Harvard Medical School, and Brigham and Women’s Hospital.

The group’s 2017 study, “Diet and exercise changes following direct-to-consumer personal genomic testing,” looked at both 23andMe and Pathway Genomics customers and found “30 percent of participants reported making a change to their diet that was specifically motivated by their (personal genetic testing) results, and 26 percent reported changing their exercise based on their (personal genetic testing) results.”

Other studies have shown much more mixed results, including a study from 2011 by researchers at the Scripps Translational Science Institute & Scripps Health, which found minimal impact either way changing behavior.

More Questions

An interesting difference between those previous studies is that they drew from customers who received an older version of 23andMe’s reports. This new survey is of customers who had access to FDA-authorized health reports. Part of the FDA’s evaluation of those reports focused on user comprehension. 23andMe was able to show that more than 90 percent of those who read the reports were able to understand the key concepts in the reports. This survey however doesn’t offer any insight into whether the difference between the old and new reports has an impact on customers’ behavior.

There are many questions raised by the survey that 23andMe researchers would like to explore further. The paramount question they would like to address is whether this survey is capturing the sentiment of a more engaged health customer, or whether the nature of 23andMe personalized genetic reports motivates positive change. But the survey results offer an intriguing first step in learning more about improving health behavior for 23andMe customers.

23andMe researchers hope to conduct follow-up studies to more rigorously measure factors related to behavior change, better establish attribution, and increase generalizability to the broader customer base. Eventually researchers hope to submit their findings for peer review and publication.

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In the latest in a series of studies by researchers looking at the impact of direct-to-consumer $\"computer-survey\"$ genetic testing, investigators found that people’s perception of risk was changed much more by a genetic test that showed a decreased risk versus one that reported an increased risk.

“You see a much bigger change for good news than bad news,” said Joshua Krieger, a doctoral candidate at MIT and one of the lead authors of the study.

These latest findings are part of ongoing collaborative research by scientists at MIT, the Broad Institute, Harvard Medical School Brigham, Women’s Hospital and 23andMe, to gauge how genetic testing affects consumers. In this study, called the Impact of Personal Genomics, or the PGen study, researchers are looking not just at how testing changes people’s perception of risk, but whether testing triggers undue stress, or leads people to flock to their doctors and burden the healthcare system.\n

\nIn the past, criticism of direct-to-consumer genetic testing included speculation that it would result in undue stress for consumers, and a “raiding of the medical commons.”

This study found no evidence to support either of those concerns – people did not burden their doctors with visits after getting their results, and they didn’t appear to overreact to those results either. But, a positive test result had a greater impact on risk perception than a negative one.

“There is an optimism bias, in that people want to believe good news,” said Krieger.\n

\nIndeed, the impact of positive news was about twice as strong as that of negative news, according to the study.

While researchers could only speculate about why there was a difference in the impact of good versus bad news – or a reported decrease in risk versus an increase – they also noted that when there was a large change in perceived risk based on the genetic test a consumer was much more likely to seek medical advice.\n

\n“Though we found good news-bad news asymmetry in risk perception changes, these changes appeared to be moderate and congruent with test results,” the study said. “Taken together, our results suggest that DTC consumers learn from their (genetic test) results and update their beliefs, but they primarily seek additional medical actions after they receive news of large and unexpected risks.”\n

\nWhile this work is important for ongoing efforts to improve how test results are reported out to consumers, it is based on 23andMe reports that are no longer offered to consumers. After an extensive and ongoing regulatory process with the FDA, 23andMe has changed the type of health information it reports to its customers. Extensive user comprehension testing, and its own research into how consumers absorb and understand the information informs 23andMe’s new health reports.

But for this study, scientists drew data from about 617 23andMe customers who enrolled in the research study before those regulatory changes were made. Researchers surveyed those customers before they received their results and again six months after they received them. While there was neither “excessive overreaction nor complete disregard of the test results,” there was indeed a difference in how certain results impacted consumers’ perception of risk.

“This research expands our understanding of how the consumers of personal genomics may react to what they perceive as elevated or diminished risk, and reminds us that perceptions are not always logical,” said Robert C. Green, a medical geneticist at Brigham and Women’s Hospital and Harvard Medical School and the principal investigator for the PGen study.

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PGen

Health Change Survey

The impact of genetic testing on perceived risk of cancer

Stay in the know.