By Joyce Tung and Amy Kiefer
<img loading="lazy" decoding="async" class="alignright size-full wp-image-2445" title="istock_000002575226xsmall" src="https://blog-api.23andme.com/wp-content/uploads/2008/12/istock_000002575226xsmall.jpg" alt="" width="282" height="426" srcset="https://blogcms.23andme.com/wp-content/uploads/2008/12/istock_000002575226xsmall.jpg 282w, https://blogcms.23andme.com/wp-content/uploads/2008/12/istock_000002575226xsmall-199x300.jpg 199w" sizes="auto, (max-width: 282px) 100vw, 282px" />
It&#8217;s been an exciting seven months since we launched <a href="https://www.23andme.com/research/" target="_blank" rel="noopener">23andWe</a>, the arm of 23andMe that gives people an unprecedented opportunity to collaborate with us on cutting-edge genetic research. Since May, the amount of data we’ve collected has grown at a fast and furious pace. For those of us who are used to the difficult and painfully slow accumulation of data in academic research projects, this information explosion has been nothing short of amazing.
From our first baby steps with “Ten Things About You” in May, to our three latest surveys – &#8220;Health Habits,&#8221; &#8220;Where Are You From?&#8221; and &#8220;What Do You Do?&#8221; – 23andWe has undergone some serious evolution. Almost every month, we have published more surveys and developed more features to help make the survey-taking experience simpler, more interesting, and more rewarding. We want to make it easy for our customers to provide truthful, good quality data, as that is the first and most important step towards doing high quality research. A big thank you to all our survey takers–we pledge to constantly work on improving this feature so we can keep you coming back for more.
We’re starting to look at genetic associations with the traits we ask about in our surveys, and we expect to have some exciting ones to report soon. But we’ve already learned some interesting things just by looking at the survey responses themselves. For example, while a few sources suggest that a higher percentage of men are left-handed than women, our data so far suggest that once you control for age this is not the case. It seems like our society is becoming more accepting of us female lefties! We’ve also seen that handedness does indeed significantly correlate with footedness. That is, left-handers are more likely to be left-footed, and right-handers are more likely to be right-footed. Similarly, handedness significantly correlates with ocular dominance, as left-handers are more likely to be left-eye dominant, and right-handers are more likely to be right-eye dominant.
And proving mom right once and for all, we&#8217;ve found that a sweet tooth does lead to more cavities. After controlling for sex and age, you&#8217;re more likely to report having many cavities (as opposed to few or none) if you reach for either something sweet or something sweet and salty when it&#8217;s time for a snack.
How is this kind of information going to usher in the era of personalized medicine? Handedness may seem like a relatively trivial trait, but it is correlated with risk for learning disability, schizophrenia, exceptional mathematical talent and other relevant traits. Understanding the biological underpinnings of what makes us choose one hand over the other for all our most delicate tasks may help us better understand the basis for these other complex traits.
As 23andWe matures we plan to start focusing more directly on health-related traits. Look for surveys in the very near future that ask about various medical conditions whose genetics is not yet understood. By combining the information customers provide in their survey responses with data from our custom chip, we can look throughout the genome for DNA variations linked to many different traits. This method can help us find genes that no one thought would be involved with a particular condition. For example, genome-wide studies on age-related macular degeneration (a leading cause of blindness) recently surprised researchers by identifying associations with genes that make components of the innate immune system. This gave scientists a whole new pathway in which to search for treatments.
We can’t guarantee that we’ll find something useful or interesting with every analysis that we do; science is a game you have to play a lot of times in order to win. But we can guarantee that we will strive to do the best research and that we will share our findings with the scientific community. By contributing to the body of knowledge on human genetics, we believe we can help bring the dream of personalized medicine a few steps closer to reality.
And all we need you to do is take some surveys.

Joyce Tung

23andWe: The First Annual Update

Since 23andWe debuted in May, we&#8217;ve asked our customers about all sorts of things: their hair color, <a href="https://www.23andme.com/topics/traits/earwax-type/">earwax consistency</a>, whether they tend to look on life&#8217;s bright side. Sometimes people have been surprised to learn that something like your susceptibility to motion sickness – or even which way the <a href="http://www.genetics.org/cgi/content/abstract/165/1/269" target="_blank" rel="noopener noreferrer">hair swirls</a> on top of your head – may be influenced by genetics.
Now we&#8217;re introducing three new surveys that ask our customers a few more thought-provoking questions that could help science understand more about genetics: 

<ol>
<li>Our new ancestry survey, &#8220;Where are You From?&#8221; inquires about the birthplaces of our customers, their parents and grandparents. We&#8217;re hoping the survey can help us do an even better job of correlating peoples&#8217; genetics to their ancestral homelands. It could also help us address questions geneticists have had little opportunity to ask in the past, such as how regional genetic differences within the United States may reflect the different ethnic backgrounds of the people who settled in the country. And finally, recent papers such as this <a href="http://hmg.oxfordjournals.org/cgi/content/abstract/17/R2/R143?maxtoshow=&amp;HITS=10&amp;hits=10&amp;RESULTFORMAT=1&amp;author1=Gregersen&amp;andorexacttitle=and&amp;andorexacttitleabs=and&amp;andorexactfulltext=and&amp;searchid=1&amp;FIRSTINDEX=0&amp;sortspec=relevance&amp;resourcetype=HWCIT" target="_blank" rel="noopener noreferrer">one</a> suggest that ancestry information can be vital to any study that tries to associate genes and traits.</li>
<li>Our second survey, &#8220;Health Habits,&#8221; asks about things like exercise, diet, smoking and drug use. It&#8217;s not that we want to determine whether there are genetic influences on whether a person smokes (though there probably are) so much as we&#8217;d like to know these things so we can see if they are more likely than genetics to account for the way people respond to certain surveys.</li>
<li>Researchers often struggle to distinguish between the contributions of nature and nurture when they study things like personality, IQ and athletic ability. Our final new survey – &#8220;What Do You Do?&#8221; – tries to account for some elements on the nurture side of the gene-environment equation.</li>
</ol>
These new surveys are a little different from some of the ones our customers have already taken. They&#8217;re not going to tell you if you&#8217;re less optimistic than average, or whether your tendency to sneeze in bright sunlight makes you a freak of nature (It doesn&#8217;t). But they&#8217;re just as critical to helping us reach our goal of advancing genetic research. So if you&#8217;re a 23andMe customer, we invite you to visit 23andWe and take our latest surveys. And if you haven&#8217;t joined the 23andMe community yet, we invite you to read more about <a href="https://www.23andme.com/research/" target="_self" rel="noopener noreferrer">23andWe</a> on our public site.

surveys — Page 2

23andWe: The First Annual Update

Three New Surveys from 23andWe Ask New Kinds of Questions

Stay in the know.