Today, 23andMe is announcing its new, advanced health membership – 23andMe+ Total Health™, which launches to new consumers in early November.

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Total Health is designed to be a comprehensive, prevention-based membership, combining clinical grade exome sequencing, biannual blood testing, and unprecedented access to clinicians trained in genetics. Total Health will also include all the reports and features offered in our existing 23andMe+ Premium Membership in addition to these new services.

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“We’re bringing the power of genetics into your personal healthcare journey,” said 23andMe’s Vice President of Genomic Health Noura Abul-Husn, M.D. Ph.D. “We’re offering comprehensive genetic testing – including exome sequencing – to help you understand your disease risks, blood testing to check on your health status, and access to clinicians with unique expertise to guide your next steps.”

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As a medical geneticist Noura said she wants people to understand how their genetic information is connected to their health. This empowers them to use that knowledge to stay healthy, she said.

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“We don’t typically see genetics being used this way in healthcare, but it can, and it should. It’s about prevention,” Noura said. “It’s personal. It’s the whole story. It’s Total Health.”

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A prevention-focused future

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Total Health delivers on our mission to help people access, understand and benefit from the human genome. This membership is for individuals who want to augment their current healthcare experience with even more direct access to comprehensive genetic testing, risk assessment in critical health areas, and personalized health plans driven by clinicians with unique knowledge and training in genetics. This is for the consumer who is actively focused on ongoing health management, longevity and direct access to even more testing so they can mitigate, or prevent, disease.

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Through the combination of critical health data, including comprehensive and personalized genetic information, blood biomarkers and personal and family medical history, the genetics-trained clinicians can provide risk assessments and help build a highly personalized, preventive health plan.

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What’s included?

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Exome sequencing

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Through advanced exome sequencing, members will receive clinician-ordered genetic testing that looks deeper into high impact genes associated with 55+ health conditions that, if detected early, may have effective preventive measures and clinical interventions. This includes screens for clinically actionable and under-diagnosed hereditary conditions related to cancer, cardiovascular, metabolic, kidney, neurological and other health conditions. This includes all genes considered medically actionable by the American College of Medical Genetics (ACMG).

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Biannual blood testing

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While genetics offers insight into the future, blood testing gives insight into the now. Total Health members will get comprehensive blood tests that assess 55+ biomarkers, including ones that go beyond your routine labs. This includes measuring things like blood sugar levels, kidney, liver and thyroid function, along with cholesterol and advanced lipoprotein levels, which offer ongoing insight for prevention and early detection. Members will receive biannual testing, allowing them to track results and measure progress all within their 23andMe account. Blood testing is initiated by a clinician and members will complete their testing through a local lab offered by a third-party provider.

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Access to clinicians trained in genetics

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Total Health members will have access to clinicians trained in genetics. Clinicians will review all blood biomarkers, genetic data and personal and family medical history to provide members with personalized risk assessments and help build a preventive health plan tailored to each individual. Members are able to engage in an annual virtual clinician consultation, as well as have ongoing messaging conversations with clinicians about their reports, progress they are making, or to ask questions.

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23andMe+ Premium Membership

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As part of Total Health, members will gain access to all the premium reports and features delivered through 23andMe+ Premium. This includes:

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FDA authorized reports offered through our Health + Ancestry Service*
Polygenic reports (powered by 23andMe research), which look at your genetic likelihood for more common conditions like high LDL cholesterol, asthma and anxiety
Pharmacogenetic reports, which help you understand how your genetics can impact how you process certain medications**
Enhanced ancestry features

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Expanding coverage

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Historically, 23andMe has offered reports using genotyping technology, a powerful, efficient and accurate way to examine DNA variants at certain pre-identified positions in the genome. The specific positions we look at are known to more commonly vary between individuals that span the entire genome.

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However, exome sequencing is an advanced, comprehensive genetic testing technology that involves reading every DNA letter in its correct order within a given piece of the genome. This provides individuals with a more complete picture, surfacing the majority of genetic variants known to be associated with disease risk.

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For example, we use genotyping for our BRCA1/BRCA2 (Selected Variants) Genetic Health Risk report*, which looks at 44 variants within the BRCA1 and BRCA2 genes associated with breast, ovarian, and prostate cancer. With exome sequencing, Total Health will include reports that look at all the thousands of variants within the coding region of the BRCA1 and BRCA2 genes. We’ll also include thousands of variants in many other genes associated with increased cancer risks.

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Our exome sequencing will go beyond cancer to also include clinical interpretations of high impact genes associated with other hereditary health conditions that, if detected early, may have effective prevention measures and clinical interventions.

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23andMe+ Total Health offers members a fuller picture of their risk for disease, helping them navigate to a healthier future.

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Availability and Eligibility

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Total Health is available for those 18 and older in the United States (excluding Hawaii, New Jersey, New York, and Rhode Island). The 23andMe+ Total Health membership costs $999, with an annual membership renewal of $499 per year.

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Learn more about 23andMe+ Total Health™ here.

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Important PGS Test Information

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*The 23andMe PGS test includes health predisposition and carrier status reports. Health predisposition reports include both reports that meet FDA requirements for genetic health risks and reports which are based on 23andMe research and have not been reviewed by the FDA. The test uses qualitative genotyping to detect select clinically relevant variants in the genomic DNA of adults from saliva for the purpose of reporting and interpreting genetic health risks and reporting carrier status. It is not intended to diagnose any disease. Your ethnicity may affect the relevance of each report and how your genetic health risk results are interpreted. Each genetic health risk report describes if a person has variants associated with a higher risk of developing a disease, but does not describe a person’s overall risk of developing the disease. The test is not intended to tell you anything about your current state of health, or to be used to make medical decisions, including whether or not you should take a medication, how much of a medication you should take, or determine any treatment. Our carrier status reports can be used to determine carrier status, but cannot determine if you have two copies of any genetic variant. These carrier reports are not intended to tell you anything about your risk for developing a disease in the future, the health of your fetus, or your newborn child’s risk of developing a particular disease later in life. For certain conditions, we provide a single report that includes information on both carrier status and genetic health risk.

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Warnings & Limitations:

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The 23andMe PGS Genetic Health Risk Report for BRCA1/BRCA2 (Selected Variants) is indicated for reporting of 44 variants in the BRCA1 and BRCA2 genes. The report describes if a person’s genetic result is associated with an increased risk of developing breast cancer and ovarian cancer and may be associated with an increased risk for prostate cancer, pancreatic cancer, and potentially other cancers. The variants included in this report do not represent the majority of the BRCA1/BRCA2 variants in people of most ethnicities. This report does not include variants in other genes linked to hereditary cancers and the absence of variants included in this report does not rule out the presence of other genetic variants that may impact cancer risk. This report is for over-the-counter use by adults over the age of 18, and provides genetic information to inform discussions with a healthcare professional. The PGS test is not a substitute for visits to a healthcare professional for recommended screenings or appropriate follow-up. Results should be confirmed by an independent genetic test prescribed by your own healthcare provider before taking any medical action. For important information and limitations regarding each genetic health risk and carrier status report, visit 23andme.com/test-info.

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**23andMe PGS Pharmacogenetics reports: The 23andMe test uses qualitative genotyping to detect 3 variants in the CYP2C19 gene, 2 variants in the DPYD gene and 1 variant in the SLCO1B1 gene in the genomic DNA of adults from saliva for the purpose of reporting and interpreting information about the processing of certain therapeutics to inform discussions with a healthcare professional. It does not describe if a person will or will not respond to a particular therapeutic. Our CYP2C19 Pharmacogenetics report provides certain information about variants associated with metabolism of some therapeutics and provides interpretive drug information regarding the potential effect of citalopram and clopidogrel therapy. Our SLCO1B1 Pharmacogenetics report provides certain information about variants associated with the processing of some therapeutics and provides interpretive drug information regarding the potential effect of simvastatin therapy. Our DPYD Pharmacogenetics report does not describe the association between detected variants and any specific therapeutic. Results for DPYD and certain CYP2C19 results should be confirmed by an independent genetic test prescribed by your own healthcare provider before taking any medical action. Warning: Test information should not be used to start, stop, or change any course of treatment and does not test for all possible variants that may affect metabolism or protein function. The PGS test is not a substitute for visits to a healthcare professional. Making changes to your current regimen can lead to harmful side effects or reduced intended benefits of your medication, therefore consult with your healthcare professional before taking any medical action. For important information and limitations regarding Pharmacogenetic reports, visit 23andme.com/test-info/pharmacogenetics.

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